Gameplay first
A player in the middle of a match does not want a pop-up. A brand does not want to be the thing that broke the moment.
The answer is to put the ad where the eye already goes: a billboard on the track, a banner at the edge of the arena. It is drawn by the game engine like any other object, and play carries on.
That is the approach behind Gadsme, available on phones, computers and consoles. See gadsme.com.